Early Work

1 ) Phase Transfer Catalysis. The Acetoacetic Ester Condensation, by H. Dupont Durst and Lanny Liebeskind, J. Org. Chem., 1974, 39, 3271.
2 ) The g-Methylthiocrotonic Ester Anion: A Versatile Bifunctional Michael Nucleophile, by Andrew S. Kende, Dimitrios Constantinides, Steven J. Lee, and L. S. Liebeskind, Tetrahedron Lett., 1975, 405.
3 ) In Situ Generation of a Solvated Zerovalent Nickel Reagent. Biaryl Formation, Andrew S. Kende, L. S. Liebeskind, and David M. Braitsch, Tetrahedron Lett., 1975, 3375.
4 ) Total Synthesis of (±)-Steganacin, Andrew S. Kende, and L. S. Liebeskind, J. Am. Chem. Soc., 1976, 98, 267.
5 ) Isosteganacin, Andrew S. Kende, L. S. Liebeskind, Clifford Kubiak, and Richard Eisenberg, J. Am. Chem. Soc., 1976, 98, 6389.
6 ) Oxidative Aryl-Benzyl Coupling. A Biomimetic Entry to Podophyllin Lactones, Andrew S. Kende, L. S. Liebeskind, John E. Mills, P. Steward Rutledge, Dennis P. Curran, J. Am. Chem. Soc., 1977, 99, 7082.
7 ) The First d 0 Metallooxaziridines. Amination of Olefins, L. S. Liebeskind, K. Barry Sharpless, Robert D. Wilson, James A. Ibers, J. Am. Chem. Soc., 1978, 100, 7061.

Organic Synthesis Using Stoichiometric Metal Complexes

8 ) A Simple Route to Metalla-2-Indane-1,3-Diones, L. S. Liebeskind, Sherrol L. Baysdon, Michael S. South, and John F. Blount, J. Organometal. Chem., 1980, 202, C73.
9 ) Reaction of o-Diiodobenzene With Alkynes and Nickel Carbonyl. Synthesis of Substituted Indenones, L. S. Liebeskind and Michael S. South, J. Org. Chem., 1980, 45, 5426.
10 ) An Organotransition Metal Synthesis of Naphthoquinones, L. S. Liebeskind, Sherrol L. Baysdon, and Michael S. South, J. Am. Chem. Soc.,1980, 102, 7397.
11 ) Synthesis and Reaction Studies of Phthaloylcobalt Cations. Application to Naphthoquinone Synthesis, Sherrol L. Baysdon and L. S. Liebeskind, Organometallics, 1982, 1,771.
12 ) Alkylation and Aldol Reactions of Iron Acyl Enolates, L. S. Liebeskind and Mark E. Welker, Organometallics, 1983, 2, 194.
13 ) A Regiospecific Total Synthesis of (±)-Nanaomycin A Using Phthaloylcobalt Complexes, Michael S. South and L. S. Liebeskind, J. Am. Chem. Soc., 1984, 106, 4181.
14 ) Unprecedented Asymmetric Induction From a Chiral Acetate Enolate Equivalent. The Condensation of ? 5 -CpFe(CO)(PPh3)COCH3 With Imines, L. S. Liebeskind, Mark E. Welker, and Virgil Goedken, J. Am. Chem. Soc., 1984, 106, 441.
15 ) A Convergent, High-Yield, Regioselective Synthesis of Benzoquinones From Maleoylcobalt Complexes and Alkynes, L. S. Liebeskind, James P. Leeds, Sherrol L. Baysdon, and Suresh Iyer, J. Am. Chem. Soc., 1984,106, 6451.
16 ) Stereoselective Aldol Condensation Reactions of Iron Acetyl Enolates, L. S. Liebeskind and Mark E. Welker, Tetrahedron Lett., 1984, 4341.
17 ) The Chemistry of ? 5 -CpCo(CO)(maleoyl) and ? 5 -CpCo(CO)(phthaloyl) Complexes, L. S. Liebeskind and Charles F. Jewell, Jr., J. Organometal. Chem., 1985, 285, 305.
18 ) A Practical Synthesis of a,b-Unsaturated Iron Acyls. Chiral Enoate Synthons, L. S. Liebeskind, Richard W. Fengl, and Mark E. Welker, Tetrahedron Lett., 1985, 3075.
19 ) Stereoselective Conjugate Addition-Alkylations of a,b-Unsaturated Iron Acyls, L. S. Liebeskind and Mark E. Welker, Tetrahedron Lett., 1985, 3079.
20 ) Synthesis, Structure, and Reactions of a ? 5 -CpCo(bisketene) Complex, Charles F. Jewell, Jr., L. S. Liebeskind, and Michael Williamson, J. Am. Chem. Soc., 1985, 107, 6715.
21 ) The Development of An Organotransition Metal Synthesis of Quinones, L. S. Liebeskind, Sherrol L. Baysdon, Michael S. South, Suresh Iyer, and James P. Leeds, Tetrahedron Symposium in Print, 1985, 41, 5839.
22 ) Phthaloylcobalt Complexes. Ligand Modifications Leading to a Practical Naphthoquinone Synthesis, L. S. Liebeskind, Sherrol L. Baysdon, Ramakrishnan Chidambaram, and Virgil Goedken, Organometallics, 1986, 5, 1086.
23 ) Transformations of Chiral Iron Complexes of Use in Organic Synthesis. Reactions of ? 5 -CpFe(PPh3)(CO)COCH3 and Related Species Leading to a Mild, Stereospecific Synthesis of b-Lactams, L. S. Liebeskind, Mark E. Welker, and Richard W. Fengl, J. Am. Chem. Soc., 1986, 108, 6328.
24 ) Regiospecific Synthesis of 2-Methoxy-3-methyl-1,4-benzoquinones From Maleoylcobalt Complexes and Alkynes via Lewis Acid Catalysis. A Highly Convergent Route to Isoquinoline Quinones, Suresh Iyer and L. S. Liebeskind, J. Am. Chem. Soc., 1987, 109, 2759.
25 ) Practical Organic Synthesis With Strained Ring Molecules. Rhodium Catalyzed Carbonylation of Cyclopropenyl Esters and Cyclopropenyl Ketones to Alpha Pyrones and of Vinyl Cyclopropenes to Phenols, by Suk H. Cho and L. S. Liebeskind, J. Org. Chem., 1987, 52, 2631.
26 ) Acyclic Stereochemical Control Using Hexacarbonyldicobalt Stabilized Propargyl Cations. A Highly Stereoselective Route to 1-D-Methylcarbapenem Precursors, by J. Siva Prasad and L. S. Liebeskind, Tetrahedron Letters, 1987, 28, 1857.
27 ) A Formal 4 + 1 Route to Alkylidene Cyclopentenediones. The First Synthetic Application of the Transition Metal Catalyzed Terminal Alkyne¤Vinylidene Rearrangement, by L. S. Liebeskind and Ramakrishnan Chidambaram, J. Am. Chem. Soc., 1987, 109, 5025.
28 ) A Synthesis of the Abietane Diterpenoid Quinone (±)-Royleanone via Maleoylcobalt Technology, by L. S. Liebeskind, Ramakrishnan Chidambaram, Sanjay Nimkar, and Dennis Liotta, Tetrahedron Lett., 1990, 31, 3723.
29 ) Ortho-Functionalization of Aromatic Ketones Via Manganation. A Synthesis of Indenols, by L. S. Liebeskind, John R. Gasdaska, Samuel J. Tremont and J. Stuart McCallum, J. Org. Chem., 1989, 54, 669.
30 ) Synthesis of 3-Alkylidene Phthalimidines by Reaction of Isocyanates With Ortho-Manganated Aromatic Ketones, by L. S. Liebeskind, Stacey A. Johnson, and J. Stuart McCallum, Tetrahedron Lett., 1990, 31, 4397.
31 ) A Synthesis of ? 4 -1,4-Naphthoquinone-h5-Pentamethylcyclopentadienyl Cobalt Complexes, by Suk H. Cho, Kevin R. Wirtz, and L. S. Liebeskind, Organometallics, 1990, 9, 3067.
32 ) Synthesis and Reactions of Enantiomerically Pure Molybdenum (-Complexes of 2H-Pyran. A General Enantioselective Synthesis of cis-3,6-Disubstituted-3,6-dihydro-2H-pyrans and cis-2,6-Disubstituted-3,4,5,6-tetrahydro-2H-pyrans, by L. S. Liebeskind, Sverker Hansson, and John F. Miller, J. Am. Chem. Soc., 1990, 112, 9660.
33 ) Saframycin Synthetic Studies, by Thomas T. Shawe and L. S. Liebeskind, Tetrahedron, 1991, 47, 5643.
34 ) Synthesis and Structural Characterization of (h4-Cyclopentadienone)(h5-cyclopentadienyl)dicarbonyl Molybdenum Hexafluorophosphate. A Template for the Stereospecific Construction of cis-4,5-Disubstituted 2-Cyclopentenones, by L. S. Liebeskind and Agnès Bombrun, J. Am. Chem. Soc., 1991, 113, 8736.
35 ) Enantiospecific Synthesis By Transformations of Chiral Pool-Derived Metal Complexes. A Strategy for the Introduction of Substituents on a Pyranose-Derived Latera-Ligand either syn or anti to the Coordinating Metal, by Almudena Rubio and L. S. Liebeskind, J. Am. Chem. Soc. 1993, 115, 891-901.
36 ) A Synthesis of Allylic Diphenylphosphinic Esters, by J. Stuart McCallum and L. S. Liebeskind, Synthesis, 1993, 819.
37 ) An Efficient Synthesis of (h5-Cyclopentadienyl)(h3-allyl)Mo(CO)2 Complexes from Allylic Diphenylphosphinates, by J. Stuart McCallum, Jeffrey Sterbenz and L. S. Liebeskind, Organometallics, 1993, 12, 927-932.
38 ) An Improved Method for the Synthesis of (? 5 -Cyclopentadienyl)(h3-allyl)Mo(CO)(NO) Cationic Complexes: The Benefit of 1,2-Dimethoxyethane as a Solvent, by Nicholas D. P. Cosford and L. S. Liebeskind, Organometallics, 1994, 13, 1498.
39 ) Stereospecific Functionalization of p-Allylmolybdenum Complexes Derived From Cyclopentenone. Toward the Stereocontrolled Construction of Substituted 2-Cyclopentenones, by Richard H. Yu, J. Stuart McCallum and L. S. Liebeskind, Organometallics, 1994, 13, 1476.
40 ) Alkylation of Enolates of Chiral Transition Metal Acyl Complexes and "Aldol-Type Additions of Chiral Enolates of Transition Metal Acyl Complexes" by J. Stuart McCallum and L. S. Liebeskind, in Stereoselective Synthesis of Organic Compounds; H. Hagemann, Ed.; Houben-Weyl: Methods of Organic Chemistry E 22; Georg Thieme Verlag: Stuttgart.
41 ) The Development of a Quinone a-Anion Synthon. Utilization of a Maleoylcobalt Complex as a Quinone Surrogate and a Dominant Role for Ligand Effects by Charles F. Jewell, Jr. and L. S. Liebeskind, Inorg. Chim. Acta, 1994, 222, 235-246.
42 ) The Synthesis, Characterization, and Configurational Lability of (? 3 -Allyl)(dicarbonyl)[hydridotris(1-pyrazolyl)borato]molybdenum Complexes Bearing Substituents at the Termini: A Thermodynamic Preference for the Anti Stereoisomer, by Y. D. Ward, L. A. Villanueva, G. D. Allred, S. C. Payne, M. A. Semones, and L. S. Liebeskind, Organometallics, 1995, 14, 4132-4156.
43 ) Stereocontrolled Oxidative Addition of Zerovalent Molybdenum to Enantiomerically Pure Allylic Acetates With Either Inversion or Retention at the Stereogenic Center, by Y. D. Ward, L. A. Villanueva, G. D. Allred, and L. S. Liebeskind, J. Am. Chem. Soc. 1996, 118, 897-898.
44 ) The Synthesis and Characterization of Stable Cationic Hydrido[tris(1-pyrazolyl)borato]Mo(CO)(NO)(? 3 -allyl) Complexes - Solid-state and Solution Evidence for an ? 2 -Allyl Structure, by L. A. Villanueva, Y. D. Ward, R. Lachicotte, and L. S. Liebeskind, Organometallic, 1996, 15, 4190.
45 ) The Preparation of Dicarbonyl[hydridotris(1-pyrazolyl)borato](? 3 -allyl)molybdenum Complexes Bearing Electron-donating Substituents (1-tert-Butyldimethylsilyl-, 1-Alkoxy-, and 1-Acetoxy-) Via the Nucleophilic Addition of Mo(CO)3(DMF)3 to Enals and Enones, by Y. D. Ward, L. A. Villanueva, G. D. Allred, and L. S. Liebeskind, Organometallic, 1996, 15, 4201.
46 ) A Synthesis of Trisquinones by Jingjun Yin and L. S. Liebeskind, J. Org. Chem., 1998, 63(17), 5726-5727.
47 ) Enantiocontrolled [5+2] Cycloaddition to h3-Pyranylmolybdenum (-Complexes. Synthesis of Substituted Oxabicyclo[3.2.1]octenes of High Enantiopurity, by Jingjun Yin and Lanny S. Liebeskind, J. Am. Chem. Soc., 1999, 121, 5811-5812.
48 ) The Stereo- and Regiocontrolled Construction of Trisubstituted Piperidines Using a TpMo(CO)2(Dihydropyridine) Scaffold (Tp = Hydridotrispyrazolylborate), by Allesandro Moretto and Lanny S. Liebeskind, J. Org. Chem., 2000, 65, 7445-7455.
49 ) ? 3 -Pyranylmolybdenum Complexes as Chiral Scaffolds for the Enantiocontrolled Construction of 2,3,6-Trisubstituted Dihydropyrans, by Jinjun Yin, Isidro Llorente, Larry Villanueva, and Lanny S. Liebeskind, J. Am. Chem. Soc., 2000, 122 (42), 10458 - 10459.
50 ) Enantiocontrolled Synthesis of Highly Functionalized Tropanes via [5+2] Cycloaddition to (3-Pyridinylmolybdenum (-Complexes by Helena Malinakova and Lanny S. Liebeskind, Org. Lett., 2000, 2(24), 3909 - 3911.
51 ) Enantiocontrolled Synthesis of Spirooxindoles Based on the [5+2] Cycloaddition of a Tp(CO)2Mo(pyridinyl) Scaffold (Tp = Hydridotrispyrazolylborate) by Helena Malinakova and Lanny S. Liebeskind, Org. Lett., 2000, 2 (25), 4083 - 4086.
52 ) Chiral Scaffolds for Enantiocontrolled Synthesis. Enantio- and Regiocontrolled [4+2] Cycloaddition to 3-Alkenyl-h3-Pyranylmolybdenum Complexes by Ramón Gómez Arrayás and Lanny S. Liebeskind, J. Am. Chem. Soc., 2001, 123, 6185-6186.
53 ) Enantiocontrolled Synthesis of 2,3,6-Trisubstituted Piperidines using h3-Dihydropyridinylmolybdenum Complexes as Chiral Scaffolds. Total Synthesis of (-)-Indolizidine 209B by Shutian Shu, Ana Alcudia, Jingjun Yin, and Lanny S. Liebeskind, J. Am. Chem. Soc. 2001, 123, 12477-12487.
54 ) A New Oxidative Demetalation Protocol for ? 3 -Molybdenum p-Complexes. Enantiocontrolled Synthesis of Unsaturated Ketones and Lactones by Ana Alcudia, Ramón Gómez Arrayás and Lanny S. Liebeskind, J. Org. Chem., 2002, 67, 5773-5778.
55 ) Enantiocontrolled Synthesis of 2,6-Disubstituted Piperidines by Desymmetrization of meso-(-(3,4,5)-Dihydropyridinylmolybdenum Complexes. Application to the Total Synthesis of (-)-Dihydropinidine and (-)-Andrachcinidine by Chutian Shu and Lanny S. Liebeskind, J. Am. Chem. Soc., 2003, 125, 2878-2879.
56 ) ? 3 -Pyranyl and h3-Pyridinyl Molybdenum p-Complexes as Chiral Scaffolds for the Enantioselective Construction of Substituted Oxa- and Aza[3.3.1]bicyclics: First Enantio- and Regiocontrolled [5+3] Cycloaddition Reactions by Ramon Gomez Arrayas and Lanny S. Liebeskind, J. Am. Chem. Soc. 2003, 125, 9026-9027.

57) Zhang, Y.; Liebeskind, L. S. J. Am. Chem. Soc. 2005, 127(32), 11258-11259.

58) Zhang, Y.; Liebeskind, L. S. J. Am. Chem. Soc. 2006, 128(2), 465-472.
59) Gomez Arrayas, R.; Yin, J.; Liebeskind, L. S. J. Am. Chem. Soc. 2007, 129(6), 1816-1825.
60) Coombs, T. C.; Lee, M. D.; Wong, H.; Armstrong, M.; Cheng, B.; Chen, W.; Moretto, A. F.; Liebeskind, L. S. J. Org. Chem. 2008, 73(3), 882-888.

61) Garnier, E. C.; Liebeskind, L. S. J. Am. Chem. Soc. 2008, 130, 7449.
62) Coombs, T. C.; Zhang, Y.; Garnier, E. C. Liebeskind, L. S. J. Am. Chem. Soc. 2009, 131, 876.

63) Cheng, B.; Liebeskind, L. S. Org. Lett. 2009, 11, 3682.
64) Chen, W.; Liebeskind, L. S. J. Am. Chem. Soc. 2009, 131, 12546.

   

 

 

 

 

 

 

 

Strained Rings in Organic Synthesis. Thermal and Metal Catalyzed Transformations

65 ) Practical Multigram Syntheses of Benzocyclobutenediones, Michael S. South and L. S. Liebeskind, J. Org. Chem., 1982, 47, 3815.
66 ) A Practical Synthesis of Some Cyclic and Acyclic Cyclobutenediones, L. S. Liebeskind and Sherrol L. Baysdon, Tetrahedron Lett., 1984,1747.
67 ) A General, Regiospecific Synthesis of Highly Substituted Quinones, L. S. Liebeskind, Suresh Iyer, and Charles F. Jewell, Jr., J. Org. Chem., 1986, 51, 3065.
68 ) A Stereoselective, Palladium Catalyzed Route to 4-Oxygenated-5-Alkylidene Cyclopentenones and 3-Oxygenated-2-Alkylidene Indanones, by L. S. Liebeskind, David Mitchell, and Bruce Foster, J. Am. Chem. Soc., 1987, 109, 7908.
69 ) Metal Mediated Routes to 5-Membered Rings, by L. S. Liebeskind, Ramakrishnan Chidambaram, David Mitchell, and Bruce Foster, Pure and Applied Chemistry, 1988, 60, 2734.
70 ) An Improved Method for the Synthesis of Substituted Cyclobutenediones, by L. S. Liebeskind, Richard W. Fengl, Kevin R. Wirtz, and Thomas T. Shawe, J. Org. Chem., 1988, 53, 2482.
71 ) Cyclobutenediones as Precursors to Quinones and Cyclopentenones, by L. S. Liebeskind, Tetrahedron Symposium in Print, 1989, 45, 3053-3060.
72 ) Synthesis of Substituted Benzocyclobutenediones, by L. S. Liebeskind, Leonard J. Lescosky, and Charles M. McSwain, Jr., J. Org. Chem., 1989, 54, 1435.
73 ) (±)-Benzoabikoviromycin. A Potential Antiviral Agent Synthesized by the Palladium Catalyzed Ring Expansion of 2-Alkynyl-2-hydroxybenzocyclobutenones, by David Mitchell and L. S. Liebeskind, J. Am. Chem. Soc., 1990, 112, 291.
74 ) Regiospecific Preparation of Cyclobutenedione Monoacetals, by L. S. Liebeskind and Kevin R. Wirtz, J. Org. Chem., 1990, 55, 5350.
75 ) Stannylcyclobutenediones as Nucleophilic Cyclobutenedione Equivalents. Synthesis of Substituted Cyclobutenediones and Cyclobutenedione Monoacetals and the Beneficial Effect of Catalytic Copper Iodide on the Stille Reaction, by L. S. Liebeskind and Richard W. Fengl, J. Org. Chem., 1990, 55, 5359.
76 ) Acid Catalyzed Ring Expansion of 1-(1-Methoxy-1,2-propadienyl)-2-cyclobuten-1-ols. Synthesis of 5-Hydroxy-5-vinyl-2-cyclopenten-1-ones and Their Stereoselective Transformation to 5-(2-Acetoxyethylidene)-2-cyclopenten-1-ones, by Guy B. Stone and L. S. Liebeskind, J. Org. Chem., 1990, 55, 4614.
77 ) Synthesis of Metallacyclopentenones by Insertion of Rhodium into Cyclobutenones, by Mark A. Huffman, L. S. Liebeskind, and William T. Pennington, Jr., Organometallics, 1990, 9, 2194.
78 ) Synthesis of Substituted Cyclobutenediones by the Palladium Catalyzed Cross-Coupling of Halocyclobutenediones with Organostannanes, by L. S. Liebeskind and Jianying Wang, Tetrahedron Lett., 1990, 31, 4293.
79 ) Insertion of Dicarbonyl h5-Indenylcobalt(I) into Cyclobutenones: The First Synthesis of Phenols From Isolated Vinylketene Complexes, by Mark A. Huffman and L. S. Liebeskind, J. Am. Chem. Soc., 1990, 112, 8617.
80) Stannylquinones. Synthesis and Utilization as Quinone Carbanion Equivalents, by L. S. Liebeskind and Bruce S. Foster, J. Am. Chem. Soc., 1990, 112, 8612.
81 ) Nickel(0)-Catalyzed Synthesis of Substituted Phenols From Cyclobutenones and Alkynes, by Mark A. Huffman and L. S. Liebeskind, J. Am. Chem. Soc., 1991, 113, 2771-2772.
82 ) Synthesis of Quinoline Quinones and 1,2,3,4-Tetrahydroquinoline Quinones via Cyclobutenediones, by L. S. Liebeskind and Jing Zhang, J. Org. Chem., 1991, 56, 6379.
83 ) Palladium-Catalyzed Oxidative Dimerization of Stannylquinones. A Simple Method for the Synthesis of Symmetrical 2,2'-Bisquinones, L. S. Liebeskind and Steven W. Riesinger, Tetrahedron. Lett., 1991, 32, 5681.
84) A Synthesis of Highly Substituted Aromatics Through Regiocontrolled Construction of Cyclobutenones Bearing Unsaturated Substituents at the 4-Position, by Damian J. Krysan, Angela Gurski, and L. S. Liebeskind, J. Am. Chem. Soc., 1992, 114. 1412.
85 ) Reaction of Cyclobutenones With Low-Valent Metal Reagents to Form h4- and h2-Vinylketene Complexes. Reaction of h4-Vinylketene Complexes With Alkynes to Form Phenols, by Mark A. Huffman, L. S. Liebeskind and William T. Pennington, Organometallics, 1992, 11, 255.
86 ) A Strategy for Generalization of the Regiospecific Synthesis of Substituted Quinones From Cyclobutenediones, by L. S. Liebeskind, Kenneth Granberg, and Jing Zhang, J. Org. Chem. 1992, 57, 4345.
87 ) Substituted Quinone Synthesis by Palladium-Copper Cocatalyzed Cross-Coupling of Stannylquinones with Aryl and Heteroaryl Halides, by L. S. Liebeskind and Steven Riesinger, J. Org. Chem., 1993, 58, 408-413.
88 ) Preparation of 3-Acyl-3-cyclobutene-1,2-diones and Related Monoacetals, by L. S. Liebeskind, Marvin S. Yu, and Richard W. Fengl, J. Org. Chem., 1993, 58, 3543-3549.
89 ) A General, Regioselective Synthesis of Substituted Benzocyclobutenedione Monoacetals, by James P. Edwards, Damian Krysan, and L. S. Liebeskind, J. Org. Chem., 1993, 58, 3942.
90 ) Rhodium(I)-Catalyzed Intramolecular Carbocyclic Ring Fusion: A New Approach to Medium-Sized-Ring Ketones, by Mark A. Huffman and L. S. Liebeskind, J. Am. Chem. Soc., 1993, 115, 4895-4896.
91 ) A Synthesis of Substituted 2-Pyrones by Carbonylative Cross-Coupling-Thermolysis of 4-Halocyclobutenones With Alkenyl, Aryl, and Heteroarylstannanes, by L. S. Liebeskind and Jianying Wang, Tetrahedron Symposium-in-Print, 1993, 49 (25), 5461-5470.
92 ) Benzannulation of Aromatic Heterocycles. A Regiocontrolled Method for Construction of Substituted Benzo- and Dibenzofurans, and Benzo- and Dibenzothiophenes, by L. S. Liebeskind and Jianying Wang, J. Org. Chem., 1993, 58, 3550-3556.
93 ) A New Process for the Regiocontrolled Synthesis of Substituted Catechols and Other 1,2-Dioxygenated Aromatics. Conjugate Addition of Vinyl-, Aryl-, and Heteroarylcopper Reagents to Cyclobutenediones Followed by Thermal Rearrangement, by Angela Gurski and L. S. Liebeskind, J. Am. Chem. Soc., 1993, 115, 6101.
94 ) 4,4'-Bicyclobutenediones: Bisquaryls, by L. S. Liebeskind, Marvin S. Yu, Richard H. Yu, Jianying Wang, and Karl S. Hagen J. Am. Chem. Soc., 1993, 115, 9048.
95 ) Benzannulation of Stannylquinones: A New Regiocontrolled Construction of Highly Substituted Naphtho- and Anthraquinones, by James P. Edwards, Damian J. Krysan, and L. S. Liebeskind, J. Am. Chem. Soc., 1993, 115, 9868.
96 ) A Method for the Stereoselective Construction of 4-Alkoxy-5-Alkylidenecyclopentenones by the Tandem Ring Expansion-Functionalization of Alkynylcyclobutenols Using a Palladium-Mercury Cocatalytic System, by L. S. Liebeskind and Agnès Bombrun, J. Org. Chem., 1994, 59, 1149.
97 ) 3-(Tri-n-butylstannyl)-2-cyclobuten-1-one: Synthesis and Stille Cross-Coupling as a Route to 3-Substituted Cyclobutenones, by L. S. Liebeskind, Guy B. Stone, and Shijie Zhang, J. Org. Chem., 1994, 59, 7917.
98 ) 2-Alkylamino-4-Cyclopentene-1,3-diones via Addition of Imidoyl Lithiates to Cyclobutenediones, by L. S. Liebeskind and Lijun Sun, J. Org. Chem., 1994, 59, 6856-6858.
99 ) Synthesis of a-Pyridone-Based Azaheteroaromatics By Intramolecular Vinylketene Cyclizations onto the C=N Bond of Nitrogen Heteroaromatics, by Angela Gurski Birchler, Fuqiang Liu, and L. S. Liebeskind, J. Org. Chem., 1994, 59, 7737.
100 ) Synthesis of 3-Hydroxy-3-cyclobutene-1,2-dione Based Amino Acids, Eric F. Campbell, Anna K. Park, William A. Kinney, Richard W. Fengl, and L. S. Liebeskind, J. Org. Chem. 1995, 60, 1470-1472.
101 ) A General Synthetic Entry to Highly-Oxygenated, Angularly-Fused Polycyclic Aromatic Compounds, by Sangho Koo and L. S. Liebeskind, J. Am. Chem. Soc., 1995, 117, 3389-3404.
102 ) The Construction of Highly-substituted Aromatics Bearing Acyl Substituents Using Cyclobutenedione Technology: Vinylketene-based Benzannulations Using 3-Acyl-4-(substituted amino)cyclobutenediones by Lijun Sun and L. S. Liebeskind, J. Org. Chem., 1995, 60, 8194-8203.
103 ) A Versatile Synthesis of 3-Substituted Indolines and Indoles, by Dawei Zhang and L. S. Liebeskind, J.Org. Chem.,1996, 61, 2594-2595..
`104 ) A Novel Construction of Highly-Substituted Xanthones, by Lijun Sun and L. S. Liebeskind, J. Am. Chem. Soc., 1996, 118, 12473.
105 ) The Regiospecific Synthesis of Angularly-Fused Xanthones via the Benzannulation of 1,2-Adducts Derived from 3-(o-Anisoyl)-4-substituted Cyclobutenediones and Their Dithianyl Derivatives, by Lijun Sun and L. S. Liebeskind, Tetrahedron Lett., 1997, 38, 3663.
106 ) The tert-Butyl Substituent as a Regiodirecting and Novel CH-Protecting Group in Cyclobutenedione-based Benzannulation Chemistry by Fuqiang Liu and L. S. Liebeskind, J. Org. Chem., 1998, 63, 2835-2844.
107 ) A Versatile Synthesis of Dihydroquinolines and Quinoline Quinones Using Cyclobutenediones. Construction of the Pyridoacridone Ring System, by Dawei Zhang, Isidro Llorente, and L. S. Liebeskind, J. Org. Chem., 1997, 62, 13.
108 ) One-Step Synthesis of Substitued a-Pyrones from Cyclobutenediones and Lithiated O-Silyl Cyanohydrins, by Pamela Mingo, Shijie Zhang, and Lanny S. Liebeskind, J. Org. Chem., 1999, 64, 2145-2148.
109 ) A Cyclobutenedione-Based Method for the Synthesis of Substituted 2-Pyridones and Dihydro-2-pyridones, by Shijie Zhang and Lanny S. Liebeskind, J. Org. Chem., 1999, 64, 4042-4049.
110 ) 3-Cyclobutenyl-1,2-dione Substituted Porphyrins. A General and Efficient Entry to Porphyrin-Quinone and Quinone-Porphyrin-Quinone Architectures, by Xianglin Shi, Sk. Rasidul Amin, and Lanny S. Liebeskind, J. Org. Chem., 2000, 65 (6), 1650 -1664.
111 ) 3-Cyclobutenyl-1,2-dione-Substituted Porphyrins. 2. A Simple and General Entry to Quinone-Porphyrin-Porphyrin-Quinone Tetrads and Related Molecules, by Xianglin Shi and Lanny S. Liebeskind, J. Org. Chem., 2000, 65 (6), 1665 -1671.
112 ) Squaric Acid Ester Based Synthesis of Echinochrome A by Eduardo Pena Cabrera and Lanny S. Liebeskind, J. Org. Chem., 2002, 67, 1689-1691.

Copper Chemistry and Bioinspired Organometallics Applied to Organic Synthesis

113 ) On the Nature of the Copper Effect" in the Stille Cross-Coupling," by Vittorio Farina, Suresh Kapadia, Bala Krishnan, Chenjie Wang, and L. S. Liebeskind, J. Org. Chem., 1994, 59, 5905-5911.
114 ) Optimized Stille Coupling Reactions Catalyzed by Palladium on Carbon with CuI as a Cocatalyst, by Gregory P. Roth, Vittorio Farina, L. S. Liebeskind, and Eduardo Pe?a-Cabrera, Tet. Lett., 1995, 36(13), 2191-2194.
115 ) Copper-Mediated Cross-coupling of Organostannanes with Organic Iodides at or Below Room Temperature, by Gary D. Allred and L. S. Liebeskind, J. Am. Chem. Soc., 1996, 118, 2748-2749.
116 ) Ambient Temperature, Ullmann-like Reductive Coupling of Aryl, Heteroaryl, and Alkenyl Halides, by S. Zhang, D. Zhang, and L. S. Liebeskind, J. Org. Chem., 1997, 62, 2312-2313.
117 ) Sulfonium Salts. Participants Par Excellence in Metal-Mediated Carbon-Carbon Bond Formation, by Jiri Srogl, Gary Allred, and L. S. Liebeskind, J. Am. Chem. Soc., 1997, 119, 12376-12377.
118 ) Efficient Pd-Catalyzed Heterobenzylic Cross-Coupling Using Sulfonium Salts as Substrates and (PhO)3P as a Supporting Ligand by Shijie Zhang, Daniel Marshall, and Lanny S. Liebeskind, J. Org. Chem., 1999, 64 (8), 2796 -2804.
119 ) Bio-organometallic Organosulfur Chemistry. Transition Metal-Catalyzed Cross-Coupling Using Coenzyme M or Thioglycolic Acid as the Leaving Group, by Jiri Srogl, Wansheng Liu, Daniel Marshall, and Lanny S. Liebeskind J. Am. Chem. Soc., 1999, 121, 9449-9450.
120 ) Thiol Ester - Boronic Acid Cross-Coupling. Catalysis Using Alkylative Activation of the Palladium Thiolate Intermediate, by Cecile Savarin, Jiri Srogl, and Lanny S. Liebeskind, Org. Lett., 2000, 2 (20), 3229-3231.
121 ) Thiol Ester - Boronic Acid Cross-Coupling. A Mechanistically Unprecedented and General Ketone Synthesis, Lanny S. Liebeskind and Jiri Srogl, J. Am. Chem. Soc., 2000, 122, 11260-11261.
122 ) Substituted Alkyne Synthesis Under Non-basic Conditions - Copper Carboxylate-mediated, Palladium-catalyzed Thioalkyne-Boronic Acid Cross-Coupling by Cecile Savarin, Jiri Srogl, and Lanny S. Liebeskind, Org. Lett., 2001, 3 (1), 91 - 93.
123) Non-Basic, Room Temperature, Palladium-Catalyzed Coupling of Aryl and Alkenyl Iodides with Boronic Acids Mediated by Copper(I) Thiophene-2-carboxylate (CuTC), by Cecile Savarin and Lanny S. Liebeskind, Org. Lett., 2001, 3(14), 2149-2152.
124 ) Heteroaromatic Thioether - Boronic Acid Cross-Coupling under Neutral Conditions by Jiri Srogl and Lanny S. Liebeskind, Org. Lett, 2002, 4(6), 979-981.
125 ) A New Catalytic Cross-Coupling Approach for the Synthesis of Protected Aryl and Heteroaryl Amidines by Carrie L. Kusturin, Lanny S. Liebeskind and William L. Neumann, Org. Lett., 2002, 4(6), 983-985.
126 ) Bioinspired Organometallic Chemistry by Lanny S. Liebeskind, Jiri Srogl, Cecile Savarin, and Concepcion Polanco, Pure Appl. Chem., 2002, 74(1), 115-122.
127 ) A Mild, Non-basic Synthesis of Thioethers. The Copper Catalyzed Coupling of Boronic Acids with N-Thio(alkyl, aryl, heteroaryl)imides by Savarin, Cecile; Srogl, Jiri; Liebeskind, Lanny S. Org. Lett. 2002, 4, 4309-4312.
128 ) Heteroaromatic Thioether-Organostannane Cross-coupling" by Masahiro Egi and Lanny S. Liebeskind, Org. Lett., 2003, 5, 801-802.
129 ) Ketone Synthesis under Neutral Conditions. Cu(I) Diphenylphosphinite-Mediated, Palladium-Catalyzed Coupling of Thiol Esters and Organostannanes" by Rüdiger Wittenberg, Jiri Srogl, Masahiro Egi, and Lanny S. Liebeskind, Org. Lett. 2003, 5, 3033-3035.
130 ) Switchable Catalysis: Modular Synthesis of Functionalized Pyrimidinones via Selective Sulfide and Halide Cross-Coupling Chemistry by Carrie Kusturin, Lanny S. Liebeskind*, Kirby Sample, Barbara Schweitzer, Jiri Srogl, and William L. Neumann*, Org. Lett., 2003, 5(23), 4349-4352.
131 ) Copper-Mediated, Palladium-Catalyzed Coupling of Thiol Esters with Aliphatic Organoboron Reagents" by Ying Yu and Lanny S. Liebeskind, J. Org. Chem.,2004, 69, 3554-3557.
132 ) Cu(I) Mediated Reductive Amination of Aryl Boronic Acids with Aryl Nitroso Compounds Under Mild Conditions by Ying Yu, Jiri Srogl, and Lanny S. Liebeskind, Org. Lett.,2004, 6, 2631-2634
133 ) Fausett, B. W.; Liebeskind, L. S. Journal of Organic Chemistry 2005, 70, 4851-4853.
134) Zhang, Z.; Liebeskind, L. S. Organic Letters 2006, 8, 4331-4333.

135) Aguilar-Aguilar, A.; Liebeskind, L. S.; Pena-Cabrera, E. Journal of Organic Chemistry 2007, 72, 8539-8542.
136) Liu, S.; Yu, Y.; Liebeskind, L. S. Organic Letters 2007, 9, 1947-1950.
137) Villalobos, J. M.; Srogl, J.; Liebeskind, L. S. Journal of the American Chemical Society 2007, 129, 15734-15735.
138) Yang, H.; Li, H.; Wittenberg, R.; Egi, M.; Huang, W.; Liebeskind, L. S. Journal of the American Chemical Society 2007, 129, 1132-1140.

139) Yang, H.; Liebeskind, L. S. Organic Letters 2007, 9, 2993-2995.

140) Li, H.; Yang, H. Liebeskind, L. S. Organic Letters 2008, 10, 4375-4378
141) Liu, S.; Liebeskind, L. S. Journal of the American Chemical Society 2008, 130, 6908-6909

142) Zhang, Z.; Yu, Y. Liebeskind, L. S. Organic Letters 2008, 10, 3005-3008

143) Musaev D. G.; Liebeskind, L. S. Organometallics 2009, 28, 4639-4642
144) Liebeskind, L. S. Yang, H.; Li, H. Angewandte Chemie International Edition 2009, 48, 1417-1421


Other Work

145 ) Silver Mediated Cyclizations of 4-Allenyl-and 4-(2-Propynyl)azetidinones. A Stereoselective Synthesis of D1-Carbapenems Via N-C3 Closure, J. Siva Prasad, L. S. Liebeskind, Tetrahedron Lett., 1988, 29, 4253.
146 ) Palladium Mediated Formation of D1- and D2-Carbapenems by Cyclofunctionalization of 4-Allenylazetidinones and 4-(2-Propynyl)azetidinones, by J. Siva Prasad, L. S. Liebeskind, Tetrahedron Lett., 1988, 29, 4257.
147 ) Palladium-Mediated 2,6-Dialkylation of N-Benzilidene Imines: Preparation of 2,6-Dialkylbenzaldehydes, by J. Stuart McCallum, John R. Gasdaska, L. S. Liebeskind, and Samuel J. Tremont, Tetrahedron Lett., 1989, 30, 4085.
148 ) A Contribution to the Design of Molecular Switches. Novel Acid-Mediated Ring-Closing - Photochemical Ring-Opening of 2,3-Bisheteroarylquinones (Heteroaryl = thienyl, furanyl, pyrrolyl) by Xiaohu Deng and Lanny S. Liebeskind, J. Am. Chem. Soc., 2001, 123, 7703-7704
149 ) Facile Enantiodivergent Approach to 5-Hydroxy-5,6-Dihydro-2(1H)-pyridones. First Total Synthesis of Both Enantiomers of Pipermethystine by Ramón Gómez Arrayás, Ana Alcudia, and Lanny S. Liebeskind, Org. Lett., 2001, 3 (21), 3381-3383.