DIRECTOR - X-ray Crystallography Center


  FACILITIES DIRECTOR SERVICES NEW STRUCTURES


Dr. Kenneth I. Hardcastle

Facilities Director

Crystallography Lab, Emory University

email:  KHardca@emory.edu 


EDUCATION

1952                 A.B., San Jose State College
1954                 M.S., University of Mississippi
1961                 Ph.D., University of Southern California

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PROFESSIONAL EXPERIENCE

1999-present        Director, X-ray Crystallograpy Center, Emory University
1963 - 1999            Professor, California State University Northridge
1994 - 2000            Visiting Faculty, California Institute of Technology
1994 - 1995            Director, Small Molecule X-Ray Lab, Beckman Institute, Caltech
1994                 Visiting Faculty, University of Bern, Bern, Switzerland
1985                 Visiting Faculty, University College London, England
1977                 NSF Faculty Fellowship, Atomics International, Canoga Park, CA
1974                 Visiting Faculty, University of Sussex, Brighton, England
1971-1972            NSF Science Faculty Fellow, MIT, Cambridge, MA
1961-1963            Post-Doctoral Fellow, Tufts University, Medford, MA
1954-1956            Chemist, Peninsula Laboratories, Mt. View, CA

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AWARDS

2003-2006       NATO Research Grant, with Mauro Botta, Universita di Torino, Italy
1998-2000       NATO Research Grant, with Mauro Botta, Universita di Torino, Italy
1996                 PRF Postdoctoral Fellow, with Jay Siegel , UCSD
1987-1992       NATO Research Grant, with Tony Deeming, University College, London, UK
1983                 Fulbright Fellow, U. Parma, Parma, Italy
1971-1972       Science Faculty Fellow, with Al Cotton, MIT  

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RECENT PUBLICATIONS

"Cobalt-Templated Radical Processes: Inter- and Intramolecular Coupling of Propargyl Radicals," J. Organomet. Chem., 578, 68-75, 1999, Melikyan, G., Deravakian, A.*, Myer, S.**, Yadegar, S.**, Hardcastle, K. I., Ciurash, J.** and Toure, P.* 
“Electron deficient bonding of benzoheterocycles to triosmium clusters: synthesis and applications to organic chemistry,” Coor. Chem. Rev., 190-192, 975-1002, 1999, Abedin, Md. J., Bergman, B., Holmquist, R., Smith, R., Rosenberg, E., Ciurash, J.**, Roe, J.*, Vazquez, V.*, Ross, C.*, Kabir, S., Roy, B., Alam, S., Azam, K.A. and Hardcastle, K.I. 
"Stereochemistry of Congested Cyclophanes Containing Chiral Spirobiindanol Phosphonates: X-ray Structure, HPLC Enantioresolution and Clathration Properties," Eur. J. Org. Chem., 2799-2806, 1999, Consiglio, G.A., Finocchiaro, P., Failla, S., Ross, C., Caccamese, S., Giudice, G. and Hardcastle, K.I. 
"Experimental Evidence for a Second Coordination Sphere Water Molecule in the Hydration Structure of YbDTPA-.  Insights for a Re-Assessment of the Relaxivity Data of GdDTPA," Eur. J. Inorg.Chem., 2000, 971-977, Hardcastle, K.I., Botta, M., Fasano, M. and Digilio, G. 
"Manganese (II) / (III) glycolates: preparation, X-ray crystallographic studies and application in radical cycloaddition reactions," Inorg. Chimica Acta, 2000, 308, 45-50, Melikyan, G., Amiryan, F.*, Visi, M.*, B. Bales and Hardcastle, K.I. 
“Phenyl/Pentafluorophenyl Interactions and the Generation of Ordered Mixed Crystals: sym-Triphenethynylbenzene and sym-Tris(perfluorophenethynyl)benzene,”, Angew. Chem.2000, 39(13) 2323-2325, Ponzini, R., Zagha, R.**, Siegel, J. and Hardcastle, K.I. 
“Carboxylation of a u3-Methylidyne Ligand from a u3-Diazo Methylidyne Triosmium Cluster,” Organomet. 2000, 18, 3519-3527, Abedin, S. M. T.**, Hardcastle, K. I., Kabir, S. E., Malik, K. M. A., Matalib, A.,** E. Rosenberg and Abedin, J.** 
“Synthesis of Oxepanes and trans-Fused Bisoxepanes via Biomimetic, endo-Regioselective Tandem Oxacyclizations of Polyepoxides,” Org. Lett., 2000, 18, 2917-2919, McDonald, F. E., Wang, X., Do, B. and Hardcastle, K. I. 
“Trinuclear Copper(I)-bipyridine Triskellion: Template/Bascule Control of Coordination Complex Stereochemistry in a Trefoil Know Precursor,” Angew. Chem.  2000, 40, 749-751, Woods, C.R., Benaglia, M.  Toyota, S., Hardcastle, K. and Siegel, J. S. 
“Tetranuclear Copper(I)-bisphenanthroline Gridwork:  Violation of the Principle of Maximal Donor Coordination Caused by Intercalation and CH-to-N Forces,” Angew. Chem.  2000, 40, 751-752,  Toyota, S., Woods, C. R., Benaglia, M., Haldimann, R.,Wärnmark, K., Hardcastle, K. and Siegel, J. S.;
"Asymmetric Sandwich-Type Polyoxoanions. Synthesis, Characterization and X-ray Crystal Structures of Diferric Complexes," Inorg. Chem., 2001, 39,2323, T. Anderson, K. I. Hardcastle, N. Okun and C. Hill.
"Experimental and Computational Studies of Nucleophilic Attack, Tautomerization, and Hydride Migration in Benzoheterocycle Triosmium Clusters"
Musaev, D. G.; Nowroozi-Isfahani, T.; Morokuma, K.; Abedin, J.; Rosenberg, E.; Hardcastle, K. I.
Organometallics; (Article); 2006; 25(1); 203-213.
"Reduced Fluorescence Quenching of Cyclodextrin-Acetylene Dye Rotaxanes"
Park, J. S.; Wilson, J. N.; Hardcastle, K. I.; Bunz, U. H. F.; Srinivasarao, M.
J. Am. Chem. Soc.; (Communication); 2006; 128(24); 7714-7715
"A Thiadiazole-Fused N,N-Dihydroquinoxaline: Antiaromatic but Isolable"
Miao, S.; Schleyer, P. v. R.; Wu, J. I.; Hardcastle, K. I.; Bunz, U. H. F.
Org. Lett.; (Letter); 2007; 9(6); 1073-1076.
"Total Syntheses of Durgamone, Nakorone, and Abudinol B via Biomimetic Oxa- and Carbacyclizations"
Tong, R.; Valentine, J. C.; McDonald, F. E.; Cao, R.; Fang, X.; Hardcastle, K. I.
J. Am. Chem. Soc.; (Communication); 2007; 129(5); 1050-1051

Revised: October 1, 2008 .

Please email your questions or comments to KHardca@emory.edu  
Copyright © 2000 Crystallography Lab   
Last modified: November 30, 2004